長崎大学 医学部
神経機能学分野（第二生理学教室）
2022
Huang L, Chin LC, Kimura K, Nakahata Y, Human placental extract delays in vitro cellular senescence through the activation of NRF2-mediated antioxidant pathway, Antioxidants (Basel). 2022, 11(8), 1545. doi: 10.3390/antiox11081545
https://doi.org/10.3390/antiox11081545
Chang PY, Chin LC, Kimura K, Nakahata Y, Human placental extract activates a wide array of gene expressions related to skin functions, Sci Rep. 2022, 12(1). 11031. doi: 10.1038/s41598-022-15270-y.
https://www.nature.com/articles/s41598-022-15270-y
Nakahata Y, Fukada Y, Molecular connections between circadian clock and health/aging, J Biochem. 2022, 171(5),473-476. doi: 10.1093/jb/mvac028.
https://academic.oup.com/jb/article/171/5/473/6564141
Maidarti M, Tarumi W, Takae S, Wiweko B, Suzuki N.
Paclitaxel is evidence to reduce growing ovarian follicle growth in mice model study. Toxicol In Vitro. 2022 Sep;83:105386.
doi: 10.1016/j.tiv.2022.105386. Epub 2022 May 15.
2021
欧文
Ahmed R, Reza HM, Shinohara K, Nakahata Y, Cellular Senescence and its Impact on the Circadian Clock, J Biochem. 2021 Oct 20:mvab115. doi: 10.1093/jb/mvab115.
Aoyama S, Kim HK, Hirooka R, Tanaka M, Shimoda T, Chijiki H, Kojima S, Sasaki K, Takahashi K, Makino S, Takizawa M, Takahashi M, Tahara Y, Shimba S, Shinohara K, Shibata S, Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock, Cell Reports, 2021, 36:109336. DOI:https://doi.org/10.1016/j.celrep.2021.109336
Ashimori A, Nakahata Y, Sato T, Fukamizu Y, Matsui T, Shinohara K and Bessho Y. Attenuated SIRT1 activity leads to PER2 cytoplasmic localization and dampens the amplitude of Bmal1 promoter-driven circadian oscillation. Front. Neurosci. 2021 May 24;15:647589. https://doi.org/10.3389/fnins.2021.647589
Khaidizar FD, Bessho Y and Nakahata Y. Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process. Int. J. Mol. Sci. 2021, 22(7), 3709; https://doi.org/10.3390/ijms22073709
Aoyama S, Nakahata Y and Shinohara K. Chrono-nutrition has potential in preventing age-related muscle loss and dysfunction. Front. Neurosci., 16 April 2021 | https://doi.org/10.3389/fnins.2021.659883
Ahmed R, Nakahata Y, Shinohara K and Bessho Y. Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases. Front. Neurosci., 25 January 2021 | https://doi.org/10.3389/fnins.2021.638122
2020
欧文
Tarumi W, Shinohara K. Olfactory Exposure to β-Caryophyllene Increases Testosterone Levels in Women's Saliva. Sex Med. 2020 Sep;8(3):525-531. doi:10.1016/j.esxm.2020.06.001. Epub 2020 Jun 16. PMID: 2561330.
Tarumi W, Shinohara K. Women's body odour during the ovulatory phase modulates testosterone and cortisol levels in men. PLoS One. 2020 Mar 31;15(3):e0230838. doi: 10.1371/journal.pone.0230838. PMID: 32231386; PMCID: PMC7108710.
Doi H, Kanai C, Tsumura N, Shinohara K, Kato N. Lack of implicit visual perspective taking in adult males with autism spectrum disorders. Res Dev Disabil. 2020 Feb 5;99:103593. doi: 10.1016/j.ridd.2020.103593. Epub ahead of print. PMID: 32035319.
Tarumi W, Shinohara K. The Effects of Essential Oil on Salivary Oxytocin Concentration in Postmenopausal Women. J Altern Complement Med. 2020 Mar;26(3):226-230. doi: 10.1089/acm.2019.0361. Epub 2020 Feb 3. PMID: 32013535.
Nuriliani A, Nakahata Y*, Ahmed R, Khaidizar FD, Matsui T, Bessho Y. Overexpression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence. Genes Cells, 25:593–602, 2020
Asai T, Abe D, Doi H, Tanaka C, Ohishi K, Maeda H, Wada T, Takahashi Y, Nakahata Y, Shinohara K,Characteristics of the BDNF Val66Met polymorphism in competitive swimmers and judo athletes, Acta Med Nagasaki 64(1) 23 - 29 2020
2019
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Doi H, Shinohara K. Low Salivary Testosterone Level Is Associated With Efficient Attention Holding by Self Face in Women. Front Behav Neurosci. 2019 Nov 29;13:261. doi: 10.3389/fnbeh.2019.00261. PMID: 31849621; PMCID: PMC6895659.
Doi H, Sulpizio S, Esposito G, Katou M, Nishina E, Iriguchi M, Honda M, Oohashi T, Bornstein MH, Shinohara K. Inaudible components of the human infant cry influence haemodynamic responses in the breast region of mothers. J Physiol Sci. 2019 Nov;69(6):1085-1096. doi: 10.1007/s12576-019-00729-x. Epub 2019 Nov 30. PMID: 31786800.
Takahata K, Horiuchi S, Tadokoro Y, Sawano E, Shinohara K. Oxytocin levels in low-risk primiparas following breast stimulation for spontaneous onset of labor: a quasi-experimental study. BMC Pregnancy Childbirth. 2019 Oct 12;19(1):351. doi: 10.1186/s12884-019-2504-3. PMID: 31604456; PMCID: PMC6790060.
Senese VP, Azhari A, Shinohara K, Doi H, Venuti P, Bornstein MH, Esposito G. Implicit associations to infant cry: Genetics and early care experiences influence caregiving propensities. Horm Behav. 2019 Feb;108:1-9. doi: 10.1016/j.yhbeh.2018.12.012. Epub 2018 Dec 27. PMID: 30592969.
Wataru Tarumi, Chizu Kumagai, Kazuyuki Shinohara：Exposure to Essential Oil Odors Increases Salivary Testosterone Concentration in Perimenopausal Women. Acta medica Nagasakiensia, 62(2), pp.49-54; 2019
Doi H, Sulpizio S, Esposito G, Katou M, Nishina E, Iriguchi M, Honda M, Oohashi T, Bornstein M H, Shinohara K: Inaudible components of the human infant cry influence haemodynamic responses in the breast region of mothers. Journal of Physiological Sciences. 69(6): 1-12, 2019
Ahmed R, Ashimori A, Iwamoto S, Matsui T, Nakahata Y*, Bessho Y. Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time. Aging (Albany NY), 11(3):950-973, 2019
邦文
篠原 一之, 樽見 航：新たな健康戦略としての「機能性香料」の提案 ヒトフェロモン等価物の応用.日本香粧品学会誌 43(3) 191-195, 2019
篠原 一之：胎児期の育ち：胎児期からの母子コミュニケーション (特集 生命(いのち)の重み) -- (子どもの「生きる」を支える). 世界の児童と母性 = Mother and child wellbeing around the world 85, 20-23, 2019
樽見 航, 土居 裕和：嗅覚を介した父子間相互作用が乳幼児の社会的絆形成に関する神経基盤に及ぼす影響. 発達研究 : 発達科学研究教育センター紀要 33, 67-75, 2019
青山 晋也：体内時計を意識した食事の時間と配分の重要性, 日本栄養士会雑誌 16(8) 8-11, 2019
2018
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Kiriishi K, Doi H, Magata N, Torisu T, Tanaka M, Ohkubo M, Haneda M, Okatomi M, Shinohara K, Ayuse T. Occlusal force predicts global motion coherence threshold in adolescent boys. BMC Pediatr. 2018 Oct 18;18(1):331. doi: 10.1186/s12887-018-1309-2. PMID: 30336772; PMCID: PMC6194662.
Bos PA, Hechler C, Beijers R, Shinohara K, Esposito G, de Weerth C. Prenatal and postnatal cortisol and testosterone are related to parental caregiving quality in fathers, but not in mothers. sychoneuroendocrinology. 2018 Nov;97:94-103. doi: 10.1016/j.psyneuen.2018.07.013. Epub 2018 Jul 8. PMID: 30015010.
Sulpizio S, Doi H, Bornstein MH, Cui J, Esposito G, Shinohara K. fNIRS reveals enhanced brain activation to female (versus male) infant directed speech (relative to adult directed speech) in Young Human Infants. Infant Behav Dev. 2018 Aug;52:89-96. doi: 10.1016/j.infbeh.2018.05.009. Epub 2018 Jun 14. PMID: 29909251; PMCID: PMC6528784.
Doi H, Fujisawa TX, Iwanaga R, Matsuzaki J, Kawasaki C, Tochigi M, Sasaki T, Kato N, Shinohara K. Association between single nucleotide polymorphisms in estrogen receptor 1/2 genes and symptomatic severity of autism spectrum disorder. Res Dev Disabil. 2018 Nov;82:20-26. doi: 10.1016/j.ridd.2018.02.014. Epub 2018 Mar 8. PMID: 29526366.
Takahata K, Horiuchi S, Tadokoro Y, Shuo T, Sawano E, Shinohara K. Effects of breast stimulation for spontaneous onset of labor on salivary oxytocin levels in low-risk pregnant women: A feasibility study. PLoS One. 2018 Feb 15;13(2):e0192757. doi: 10.1371/journal.pone.0192757. PMID: 29447299; PMCID:
PMC5813971.
Truzzi A, Poquérusse J, Setoh P, Shinohara K, Bornstein MH, Esposito G. Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations. Dev Psychobiol. 2018 Apr;60(3):333-339. doi: 10.1002/dev.21606. Epub 2018 Jan 22. PMID: 29355918; PMCID: PMC5867267.
Nakahata Y*, Yasukawa S, Khaidizar FD, Shimba S, Matsui T, Bessho Y. Bmal1-deficient mouse fibroblast cells do not provide premature cellular senescence in vitro. Chronobiol Int. 35(5): 730-738, 2018.
2017
欧文
Tadokoro Y, Horiuchi S, Takahata K, Shuo T, Sawano E, Shinohara K. Changes in salivary oxytocin after inhalation of clary sage essential oil scent in term-pregnant women: a feasibility pilot study. BMC Res Notes. 2017 Dec 8;10(1):717. doi: 10.1186/s13104-017-3053-3. PMID: 29216912; PMCID: PMC5721455.
Sulpizio S, Kuroda K, Dalsasso M, Asakawa T, Bornstein MH, Doi H, Esposito G, Shinohara K. Discriminating between mothers' infant- and adult-directed speech: Cross-linguistic generalizability from Japanese to Italian and German. Neurosci Res. 2018 Aug;133:21-27. doi: 10.1016/j.neures.2017.10.008. Epub 2017 Oct 20. PMID: 29061319; PMCID: PMC5910280.
Bonassi A, Ghilardi T, Truzzi A, Cataldo I, Azhari A, Setoh P, Shinohara K, Esposito G. Dataset on genetic and physiological adults׳ responses to social distress. Data Brief. 2017 Jul 5;13:742-748. doi: 10.1016/j.dib.2017.06.057. PMID: 28748210; PMCID: PMC5512186.
Doi H, Shinohara K. fNIRS Studies on Hemispheric Asymmetry in Atypical Neural Function in Developmental Disorders. Front Hum Neurosci. 2017 Apr 12;11:137. doi: 10.3389/fnhum.2017.00137. PMID: 28446869; PMCID: PMC5388750.
Abe D, Doi H, Asai T, Kimura M, Wada T, Takahashi Y, Matsumoto T, Shinohara K. Association between COMT Val158Met polymorphism and competition results of competitive swimmers. J Sports Sci. 2018 Feb;36(4):393-397. doi: 10.1080/02640414.2017.1309058. Epub 2017 Apr 3. PMID: 28368213.
Shinohara K, Doi H, Kumagai C, Sawano E, Tarumi W. Effects of essential oil exposure on salivary estrogen concentration in perimenopausal women. Neuro Endocrinol Lett. 2017 Jan;37(8):567-572. PMID: 28326753.
Esposito G, Setoh P, Shinohara K, Bornstein MH. The development of attachment: Integrating genes, brain, behavior, and environment. Behav Brain Res. 2017 May 15;325(Pt B):87-89. doi: 10.1016/j.bbr.2017.03.025. Epub 2017 Mar 18. PMID: 28322913; PMCID: PMC5860659.
Wang X, Liang S, Fujisawa TX, Nishitani S, Tomoda A, Zou M, Li Y, Wu L, Shinohara K. Association of estrogen receptor alpha polymorphisms with symptoms of autism among Chinese Han children. Neuro Endocrinol Lett. 2016 Nov;37(6):439-444. PMID: 28315628.
Truzzi A, Bornstein MH, Senese VP, Shinohara K, Setoh P, Esposito G. Serotonin Transporter Gene Polymorphisms and Early Parent-Infant Interactions Are Related to Adult Male Heart Rate Response to Female Crying. Front Physiol. 2017 Feb 28;8:111. doi: 10.3389/fphys.2017.00111. PMID: 28293197; PMCID: PMC5329096.
Niwayama R, Nishitani S, Takamura T, Shinohara K, Honda S, Miyamura T, Nakao Y, Oishi K, Araki-Nagahashi M. Oxytocin Mediates a Calming Effect on Postpartum Mood in Primiparous Mothers. Breastfeed Med. 2017 Mar;12:103-109. doi: 10.1089/bfm.2016.0052. Epub 2017 Jan 19. PMID: 28103103.
Doi H, Morikawa M, Inadomi N, Aikawa K, Uetani M, Shinohara K. Neural correlates of babyish adult face processing in men. Neuropsychologia. 2017 Mar;97:9-17. doi: 10.1016/j.neuropsychologia.2017.01.017. Epub 2017 Jan 14. PMID: 28095312.
Esposito G, Truzzi A, Setoh P, Putnick DL, Shinohara K, Bornstein MH. Genetic predispositions and parental bonding interact to shape adults' physiological responses to social distress. Behav Brain Res. 2017 May 15;325(Pt B):156-162. doi: 10.1016/j.bbr.2016.06.042. Epub 2016 Jun 22. PMID: 27343933; PMCID: PMC5859575.
Senese VP, Shinohara K, Esposito G, Doi H, Venuti P, Bornstein MH. Implicit association to infant faces: Genetics, early care experiences, and cultural factors influence caregiving propensities. Behav Brain Res. 2017 May 15;325(Pt B):163-172. doi: 10.1016/j.bbr.2016.09.040. Epub 2016 Sep 17. PMID: 27650102;
PMCID: PMC5860658.
Sawano E, Doi H, Nagai T, Ikeda S, Shinohara K. Interactive effects of 5-HTTLPR genotype and rearing environment on affective attitude towards own infant in Japanese mothers. Behav Brain Res. 2017 May 15;325(Pt B):173-180. doi: 10.1016/j.bbr.2016.11.001. Epub 2016 Nov 2. PMID: 27816559.
Khaidizar FD, Nakahata Y*, Kume A, Sumizawa K, Kohno K, Matsui T, Bessho Y. Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells. Genes Cells, 22(12): 982-992, 2017.
邦文
樽見航, 篠原一之,アロマテラピーの可能性, 日本味と匂学会誌 24(2), 59-66, 2017
土居裕和、篠原一之 恋愛・結婚の心理・神経生物学 映像情報メディア学会誌 71(5), 630-633, 2017.
土居裕和、篠原一之 注意の生理学的指標とその社会性認知研究への 応用 Clinical Neuroscience, 35, 971-975, 2017
松本 高明, 内藤 祐子, 和田 壮生, 高橋 雄介, 和田 匡史, 地神 裕史, 阿部 太輔, 篠原 一之, 土居 裕和, 井上 大輔 男性競泳選手の試合に伴う唾液中ストレスホルモンの変動 国士舘大学体育研究所報 35, 97-99